In Dysphoria Mundi, Paul B. Preciado has written a mutant text assembled from essays, philosophy, poetry and autofiction that captures a moment of profound change and possibility. Rooted in the isolation of the Covid-19 pandemic, and taking account of the societal convulsions that have ensued, Preciado tries to make sense of our times from within the swirl of a revolutionary present moment. The central thesis of this monumental work is that dysphoria, to be understood properly, should not be seen as a mental illness but rather as the condition that defines our times. Dysphoria is an abyss that separates a patriarchal, colonial and capitalist order hurtling toward its end from a new way of being that, until now, has been seen as unproductive and abnormal but is in fact the way out of our current predicament. With echoes of visionaries such as William S. Burroughs and Kathy Acker, Preciado’s theoretical writing is propelled by lyric power while providing us with a critical toolbox full of new concepts that can guide our thinking and our actions: transition, cognitive emancipation, denormalization, disidentification, ‘electronic heroin’, digital coups, necro-kitsch. Dysphoria Mundi is Preciado’s most accessible and significant work to date, in which he makes sense of a world in ruins around us and maps a joyous, radical way forward.